Sigourney WeaverDana Barrett
Harold RamisDr. Egon Spengler
Ernie HudsonWinston Zeddemore
Annie PottsJanine Melnitz
Peter MacNicolDr. Janosz Poha
David MarguliesMayor Lenny
Kurt FullerJack Hardemeyer
Janet MargolinThe Prosecutor
William T. DeutschendorfBaby Oscar
Henry J. Deutschendorf IIBaby Oscar
Michael P. MoranFrank the Doorman
Mordecai LawnerMan with a Ticket
Susanna BoehmYoung Woman on Crutches
Mary Ellen TrainorBrownstone Mother
Christopher VillaseñorBrownstone Boy #1
Jason ReitmanBrownstone Boy #2
Aaron LustigNorman the Producer
Page LeongSpengler's Assistant
Mark SchneiderArguing Couple
Valery PappasArguing Couple
Catherine ReitmanGirl with Puppy
Richard ForonjyCon Ed Supervisor
Sharon KramerStenographer
Walter FlanaganRudy the Museum Guard
Bobby BrownMayor's Doorman
Christopher NeameMaitre D'
Judy OvitzSlimed Restaurant Patron
Tom DuganRestaurant Cop #1
Angelo DimascioRestaurant Cop #2
Robert Alan BeuthStore Manager
Ralph MonacoPolice Sergeant
Ron CumminsPolice Lieutenant
Cheech MarinDock Supervisor
Yvette CruiseMaria, Dana's Maid
Ray GlanzmannDetective #2
Alex ZimmermanDetective #3
Brian Doyle-MurrayPsychiatrist
Louise TroyWoman with Fur Coat
Douglas SealePlaza Hotel Man
Ben SteinPublic Works Official
Erik HollandFire Commissioner
Philip Baker HallPolice Commissioner
Steve BakerTelephone Man (uncredited)
Trish CookNun at Statue of Liberty (uncredited)
Kevin DunnMilton Angland (uncredited)
Ryan FrancisBrownstone Boy #3 (uncredited)
Tyra Reneé FullerDriver (uncredited)
Jim FyfeScoleri Brother / Ghost Jogger (uncredited)
George GerardMan in Cab (uncredited)
Donna GuidryArt Restoration Student (uncredited)
Tim LawrenceScoleri Brother (uncredited)
Peter PapageorgioSpectator (uncredited)
Kariim RatcliffCrowd Member (uncredited)
Ivan ReitmanMan Walking Outside Firehouse / Slimer (voice) (uncredited)
Ira S. RosensteinStage Manager (uncredited)
Felix SillaCourtroom Spectator (uncredited)
Max von SydowVigo (voice) (uncredited)
Chloe WebbElaine (uncredited)
Justin Michael WoodsBaby on the Street (uncredited)