Joaquin PhoenixLarry "Doc" Sportello
Josh BrolinLt. Det. Christian F. "Bigfoot" Bjornsen
Katherine WaterstonShasta Fay Hepworth
Reese WitherspoonDeputy D.A. Penny Kimball
Benicio del ToroSauncho Smilax, Esq.
Jena MaloneHope Harlingen
Joanna NewsomSortilège, who is also the narrator
Jordan Christian HearnDenis
Maya RudolphPetunia Leeway
Michael Kenneth WilliamsTariq Khalil
Martin ShortDr. Rudy Blatnoyd, D.D.S.
Sasha PieterseJaponica Fenway
Martin DonovanCrocker Fenway
Eric RobertsMichael Z. "Mickey" Wolfmann
Serena Scott ThomasSloane Wolfmann
Christopher Allen NelsonGlenn Charlock
Timothy SimonsAgent Borderline
Taylor BoninEnsenada Slim
Martin DewDr. Buddy Tubeside
Catherine Haena KimNews Reporter
Vivienne KhalediAmethyst Harlingen
Andrew SimpsonRiggs Warbling
Joe DiolettoCop with Bigfoot
Jack KellyBurke Stodger (archive footage)
BelladonnaClancy Charlock
Alina GattiHowdy Doper's Phone Voice (voice)
Wilson BethelLAPD Officer #1
Anders HolmLAPD Officer #2
Emmet UnverzagtBigfoot's Kid
Erica SullivanDr. Lily Hammer
Eva FisherDr. Threeply's Assistant #1
Jackie Michele JohnsonDr. Threeply's Assistant #2
Keith JardinePuck Beaverton
Delaina MitchellMrs. Chastity Bjornsen
Michael CotterRhus Frothingham
Peter McRobbieAdrian Prussia
Shannon C. SullivanAdrian Prussia's Secretary
Samantha LemoleGolden Fang Mother
Madison LeisleGolden Fang Daughter
Liam Van JoostenGolden Fang Son
Matt DoyleGolden Fang Father
Christian WilliamsSmedley
Jefferson MaysDr. Threeply
Scott AschenbrennerJesus Guard (uncredited)
Christina BobrowskyPatient (uncredited)
Peter BonillaPolice Officer (uncredited)
Gregoer BoruRecording Tech (uncredited)
Marianne BourgBeach Girl (uncredited)
Toyia BrownHarmony (uncredited)
Stu BrumbaughGroupie (uncredited)
Seth CashDetective (uncredited)
Laura Lyon RossiGroupie (uncredited)
Ashleigh BillerPatient (uncredited)
Elizabeth ColungaPatient (uncredited)
Emma CooperGroupie (uncredited)
Nick de GraffenreidPatient (uncredited)
Adam DorseyJesus Guard (uncredited)
Ken EdlingJudge (uncredited)
Jenna EmeryGroupie (uncredited)
Al FunctionBiker (uncredited)
Brandy FutchFlight Attendant (uncredited)
Lauren GoncherDental Assistant (uncredited)
Ellen HoChinese Waitress (uncredited)
Jessica HussSpeed Freak (uncredited)
Robert PeoplesPatient (uncredited)
Dallas JamesAuto Mechanic (uncredited)
Christopher Karl JohnsonMr. Robinson (uncredited)
Timothy LallyCommando (uncredited)
Adeana LaneBeach Girl (uncredited)
Kira LeggGroupie (uncredited)
Tracy Ann LisaDistrict Attorney (uncredited)
Blue LoLanPatient (uncredited)
Jacob LymanMormon FBI Agent (uncredited)
Amanda MaddoxFlight Attendant (uncredited)
Emilee MadrakGroupie (uncredited)
Kirstin MastersDental Assistant (uncredited)
Zach McMahonPolice Officer (uncredited)
Chelsea O'ToolePatient (uncredited)
Shaun ParkerCommando (uncredited)
Rodney J. RichardsAdrian Prussia's Friend (uncredited)
Philip RooseveltHippie in Commune (uncredited)
Osamu SaitoJapanese Waiter (uncredited)
Joel ShockPolice Officer (uncredited)
Matthew SkomoDetective (uncredited)
Chantal ThuyGroupie (uncredited)
Diana Elizabeth TorresLourdes (uncredited)
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